Cephamycins, a New Family of β-Lactam Antibiotics I. Production by Actinomycetes, Including Streptomyces lactamdurans sp. n

β-Lactam Antibiotics Renaissance.

Since the 1940s β-lactam antibiotics have been used to treat bacterial infections. However, emergence and dissemination of β-lactam resistance has reached the point where many marketed β-lactams no longer are clinically effective. The increasing prevalence of multidrug-resistant bacteria and the progressive withdrawal of pharmaceutical companies from antibiotic research have evoked a strong rea...

Kitamycins, new antimycin antibiotics produced by Streptomyces sp.

In the course of our screening program for plant growth inhibitors, Streptomyces sp. K385 isolated from a soil sample collected in OkayamaJapan, was found to produce kitamycin A (1) and B (2), new antimycin type antibiotics, together with known antimycin type antibiotics, antimycin A1? A2a, A3, A4a1?2), urauchimycin B (3)3), and deisovalerylblastmycin (4).4?5) This study describes the fermentat...

Degradation of β-lactam antibiotics

Recent developments in the chemistry and biology of βlactam antibiotics which culminated with the introduction of several clinically useful classical and nonclassical β-lactams have been most thrilling and highly rewarding. While this review touches upon the historical development of β-lactams and their reactivity in a nutshell, it provides an overview of various aspects of chemical and enzymat...

A new species of Streptomyces producing virginiamycin family antibiotics.

Landomycins, new angucycline antibiotics from Streptomyces sp. I. Structural studies on landomycins A-D.

The chemical structure of the new angucycline antibiotic landomycin A has been elucidated via chemical and spectroscopic methods, in particular by 2D NMR correlation spectroscopy, e.g., 1H, 1H-COSY, 13C, 1H-COSY, correlation spectroscopy via long-range-couplings and heteronuclear multiple bond connectivity spectroscopy sequences. The spectroscopic investigations were carried out principally wit...